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La Jolla, CA, United States (on-site)
17 days ago
Chicago, IL, United States (hybrid)
25 days ago
Pearl River, NY, United States (on-site)
30+ days ago
La Jolla, California, United States (on-site)
17 days ago


The key purpose of this position is to influence and advance the early candidate substrate from a physical, chemical, drug delivery, and bioperformance perspective through close collaboration with partners on the Discovery project teams and in Pharmaceutical Science.  You will need to act as a resident pharmaceutical science subject matter expert to inform, educate and influence Discovery teams in finding New Chemical Entities (NCEs) with desirable drug delivery and performance properties.  This will include assessment of in silico, in vitro and in vivo data as well as design of stage appropriate formulations for preclinical studies.  An awareness of later stage development needs as well as an understanding of the disease state and biology will help to enable the definition of the required design elements.


  • Closely collaborate with Drug Discovery partners to evaluate molecular attributes relevant to drug delivery and influence team strategies
  • Design and develop fit for purpose preclinical formulations (traditional and enabling) to enable robust candidate selection and progression
  • Assess and clearly communicate drug delivery and performance risks (using in silico, in vitro and in vivo data as well as sound scientific principles)
  • Assess solid form aspects of molecular substrate and communicate risks
  • Maintain an awareness of and contribute to scientific literature; actively apply new concepts as appropriate
  • Conduct novel research and present significant findings via internal and external presentations or publications

Organizational Relationships:

This position will interface with multidisciplinary teams and work closely with colleagues in Medicinal Chemistry, Biology, Drug Safety and Pharmacokinetics Dynamics & Metabolism.  Strong relationships with Clinical, Analytical, Materials Science, Biopharmaceutics, and late-stage Formulation colleagues are also expected.

Education and Experience:

M.S. with >5 years of relevant experience or PhD in Pharmaceutics, Chemistry, Medicinal Chemistry, Physical Chemistry, or Biophysics

Technical Skills Experience:

Skills in the following areas are required for this position:

  • Computational chemistry tools to predict physical properties and the translation of molecular properties to predict bio performance
  • Modeling of oral absorption phenomena and the interpretation of in vitro/in vivo ADME data
  • Design of typical formulation approaches and routes of administration across multiple species
  • Strong organizational, interpersonal, written, and verbal communication skills
  • Strong scientific leadership and direction of new technology initiatives
  • Application of fundamental principles to solve complex problems


Candidates must have the ability to perform laboratory work. 

Relocation support available

Job Information

  • Job ID: 66761268
  • Workplace Type: On-Site
  • Location:
    La Jolla, California, United States
  • Company Name For Job: Pfizer
  • Position Title: Senior Scientist, Molecular Pharmaceutics, Drug Product Design
  • Area of Focus: Pharmaceutical
  • Job Function: Chemist
  • Job Type: Full-Time
  • Job Duration: Indefinite
  • Min Education: Master's Degree
  • Min Experience: 5-7 Years
  • Required Travel: 0-10%

Please refer to the company's website or job descriptions to learn more about them.

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